Improvement of FK506 production via metabolic engineering-guided combinational strategies in Streptomyces tsukubaensis

BACKGROUND: FK506, a macrolide mainly with immunosuppressive activity, can be produced by various Streptomyces strains. However, one of the major challenges in the fermentation of FK506 is its insufficient production, resulting in high fermentation costs and environmental burdens. Herein, we tried t...

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Detalles Bibliográficos
Autores principales: Wu, Qing-Bin, Zhang, Xiao-Ying, Chen, Xin-Ai, Li, Yong-Quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8383387/
https://www.ncbi.nlm.nih.gov/pubmed/34425854
http://dx.doi.org/10.1186/s12934-021-01660-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8383387/
https://www.ncbi.nlm.nih.gov/pubmed/34425854
http://dx.doi.org/10.1186/s12934-021-01660-w

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