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Improvement of FK506 production via metabolic engineering-guided combinational strategies in Streptomyces tsukubaensis
BACKGROUND: FK506, a macrolide mainly with immunosuppressive activity, can be produced by various Streptomyces strains. However, one of the major challenges in the fermentation of FK506 is its insufficient production, resulting in high fermentation costs and environmental burdens. Herein, we tried t...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8383387/ https://www.ncbi.nlm.nih.gov/pubmed/34425854 http://dx.doi.org/10.1186/s12934-021-01660-w |