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Knockdown of ALDH1A3 reduces breast cancer stem cell marker CD44 via the miR-7-TGFBR2-Smad3-CD44 regulatory axis

Inhibition of aldehyde dehydrogenase 1 family member A3 (ALDH1A3) has been revealed to lead to significant increase of microRNA (miR)-7 expression and decrease of CD44 expression in breast cancer stem cells (BCSCs), however the mechanism is not clear. The aim of the present study was to investigate...

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Detalles Bibliográficos
Autores principales: Pan, Meng, Li, Miao, Guo, Mei, Zhou, Huiying, Xu, Hui, Zhao, Fengshu, Mei, Feng, Xue, Rui, Dou, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8383762/
https://www.ncbi.nlm.nih.gov/pubmed/34504547
http://dx.doi.org/10.3892/etm.2021.10527