FANCD2-Associated Nuclease 1 Partially Compensates for the Lack of Exonuclease 1 in Mismatch Repair

Germline mutations in the mismatch repair (MMR) genes MSH2, MSH6, MLH1, and PMS2 are linked to cancer of the colon and other organs, characterized by microsatellite instability and a large increase in mutation frequency. Unexpectedly, mutations in EXO1, encoding the only exonuclease genetically impl...

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Detalles Bibliográficos
Autores principales: Kratz, Katja, Artola-Borán, Mariela, Kobayashi-Era, Saho, Koh, Gene, Oliveira, Goncalo, Kobayashi, Shunsuke, Oliveira, Andreia, Zou, Xueqing, Richter, Julia, Tsuda, Masataka, Sasanuma, Hiroyuki, Takeda, Shunichi, Loizou, Joanna I., Sartori, Alessandro A., Nik-Zainal, Serena, Jiricny, Josef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8384067/
https://www.ncbi.nlm.nih.gov/pubmed/34228493
http://dx.doi.org/10.1128/MCB.00303-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8384067/
https://www.ncbi.nlm.nih.gov/pubmed/34228493
http://dx.doi.org/10.1128/MCB.00303-21

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