Loss of N(1)-methylation of G37 in tRNA induces ribosome stalling and reprograms gene expression

N(1)-methylation of G37 is required for a subset of tRNAs to maintain the translational reading-frame. While loss of m(1)G37 increases ribosomal +1 frameshifting, whether it incurs additional translational defects is unknown. Here, we address this question by applying ribosome profiling to gain a ge...

Descripción completa

Detalles Bibliográficos
Autores principales: Masuda, Isao, Hwang, Jae-Yeon, Christian, Thomas, Maharjan, Sunita, Mohammad, Fuad, Gamper, Howard, Buskirk, Allen R, Hou, Ya-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Microbiology and Infectious Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8384417/
https://www.ncbi.nlm.nih.gov/pubmed/34382933
http://dx.doi.org/10.7554/eLife.70619

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8384417/
https://www.ncbi.nlm.nih.gov/pubmed/34382933
http://dx.doi.org/10.7554/eLife.70619

Ejemplares similares