Expanding the binding specificity for RNA recognition by a PUF domain

The ability to design a protein to bind specifically to a target RNA enables numerous applications, with the modular architecture of the PUF domain lending itself to new RNA-binding specificities. For each repeat of the Pumilio-1 PUF domain, we generate a library that contains the 8,000 possible com...

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Detalles Bibliográficos
Autores principales: Zhou, Wei, Melamed, Daniel, Banyai, Gabor, Meyer, Cindy, Tuschl, Thomas, Wickens, Marvin, Cao, Junyue, Fields, Stanley
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8384837/
https://www.ncbi.nlm.nih.gov/pubmed/34429425
http://dx.doi.org/10.1038/s41467-021-25433-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8384837/
https://www.ncbi.nlm.nih.gov/pubmed/34429425
http://dx.doi.org/10.1038/s41467-021-25433-6

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