The chaperone HSPB1 prepares protein aggregates for resolubilization by HSP70

In human cells under stress conditions, misfolded polypeptides can form potentially cytotoxic insoluble aggregates. To eliminate aggregates, the HSP70 chaperone machinery extracts and resolubilizes polypeptides for triage to refolding or degradation. Yeast and bacterial chaperones of the small heat-...

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Detalles Bibliográficos
Autores principales: Gonçalves, Conrado C., Sharon, Itai, Schmeing, T. Martin, Ramos, Carlos H. I., Young, Jason C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8384840/
https://www.ncbi.nlm.nih.gov/pubmed/34429462
http://dx.doi.org/10.1038/s41598-021-96518-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8384840/
https://www.ncbi.nlm.nih.gov/pubmed/34429462
http://dx.doi.org/10.1038/s41598-021-96518-x

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