Utilizing thermal proteome profiling to identify the molecular targets of anti-leishmanial compounds

Here, we detail our optimized protocol for the identification of drug targets in Leishmania donovani using thermal proteome profiling. This approach is based on the principle that binding of a drug to its protein target can significantly alter the thermal stability of that protein. By monitoring cha...

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Detalles Bibliográficos
Autores principales: Corpas-Lopez, Victoriano, Wyllie, Susan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8384900/
https://www.ncbi.nlm.nih.gov/pubmed/34467225
http://dx.doi.org/10.1016/j.xpro.2021.100704

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8384900/
https://www.ncbi.nlm.nih.gov/pubmed/34467225
http://dx.doi.org/10.1016/j.xpro.2021.100704

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