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Utilizing thermal proteome profiling to identify the molecular targets of anti-leishmanial compounds
Here, we detail our optimized protocol for the identification of drug targets in Leishmania donovani using thermal proteome profiling. This approach is based on the principle that binding of a drug to its protein target can significantly alter the thermal stability of that protein. By monitoring cha...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8384900/ https://www.ncbi.nlm.nih.gov/pubmed/34467225 http://dx.doi.org/10.1016/j.xpro.2021.100704 |