Covalent inhibition of hAChE by organophosphates causes homodimer dissociation through long-range allosteric effects

Acetylcholinesterase (EC 3.1.1.7), a key acetylcholine-hydrolyzing enzyme in cholinergic neurotransmission, is present in a variety of states in situ, including monomers, C-terminally disulfide-linked homodimers, homotetramers, and up to three tetramers covalently attached to structural subunits. Co...

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Detalles Bibliográficos
Autores principales: Blumenthal, Donald K., Cheng, Xiaolin, Fajer, Mikolai, Ho, Kwok-Yiu, Rohrer, Jacqueline, Gerlits, Oksana, Taylor, Palmer, Juneja, Puneet, Kovalevsky, Andrey, Radić, Zoran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8384907/
https://www.ncbi.nlm.nih.gov/pubmed/34324828
http://dx.doi.org/10.1016/j.jbc.2021.101007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8384907/
https://www.ncbi.nlm.nih.gov/pubmed/34324828
http://dx.doi.org/10.1016/j.jbc.2021.101007

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