Cargando…

Covalent inhibition of hAChE by organophosphates causes homodimer dissociation through long-range allosteric effects

Acetylcholinesterase (EC 3.1.1.7), a key acetylcholine-hydrolyzing enzyme in cholinergic neurotransmission, is present in a variety of states in situ, including monomers, C-terminally disulfide-linked homodimers, homotetramers, and up to three tetramers covalently attached to structural subunits. Co...

Descripción completa

Detalles Bibliográficos
Autores principales:	Blumenthal, Donald K., Cheng, Xiaolin, Fajer, Mikolai, Ho, Kwok-Yiu, Rohrer, Jacqueline, Gerlits, Oksana, Taylor, Palmer, Juneja, Puneet, Kovalevsky, Andrey, Radić, Zoran
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8384907/ https://www.ncbi.nlm.nih.gov/pubmed/34324828 http://dx.doi.org/10.1016/j.jbc.2021.101007

Ejemplares similares

Hach winik
por: Dewever-Plana, Miquel, 1961-
Publicado: (2009)

Room temperature crystallography of human acetylcholinesterase bound to a substrate analogue 4K-TMA: Towards a neutron structure
por: Gerlits, Oksana, et al.
Publicado: (2021)

Amor se escribe sin hache
por: Jardiel Poncela, Enrique, 1901-1952
Publicado: (1999)

Amor se escribe sin hache
por: Jardiel Poncela, Enrique, 1901-1952
Publicado: (1997)

Amor se escribe sin hache : novela casi cosmopolita
por: Jardiel Poncela, Enrique, 1901-1952
Publicado: (2002)

A covalent homodimer probing early oligomers along amyloid aggregation
por: Halabelian, Levon, et al.
Publicado: (2015)

Insights into the Phosphoryl Transfer Catalyzed by cAMP-Dependent Protein Kinase: An X-ray Crystallographic Study of Complexes with Various Metals and Peptide Substrate SP20
por: Gerlits, Oksana, et al.
Publicado: (2013)

Oxime Therapy for Brain AChE Reactivation and Neuroprotection after Organophosphate Poisoning
por: Kuznetsova, Darya A., et al.
Publicado: (2022)

Imidazole Aldoximes Effective in Assisting Butyrylcholinesterase Catalysis of Organophosphate Detoxification
por: Sit, Rakesh K., et al.
Publicado: (2014)

Zooming in on protons: Neutron structure of protein kinase A trapped in a product complex
por: Gerlits, Oksana, et al.
Publicado: (2019)

Network Toxicology and Molecular Docking to Investigate the Non-AChE Mechanisms of Organophosphate-Induced Neurodevelopmental Toxicity
por: Souza, Juliana Alves da Costa Ribeiro, et al.
Publicado: (2023)

Replica-Exchange Accelerated Molecular Dynamics (REXAMD) Applied to Thermodynamic Integration
por: Fajer, Mikolai, et al.
Publicado: (2008)

In silico analysis of selected nutrition rich fruit of Bunch berry (Lantana camara) constituents as human acetylcholinesterase (hAchE), carbonic anhydrase II (hCA-II) and carboxylesterase 1 (hCES-1) inhibitory agents
por: Surya Prakash, V., et al.
Publicado: (2023)

Neutron Diffraction Reveals Hydrogen Bonds Critical for cGMP-Selective Activation: Insights for cGMP-Dependent Protein Kinase Agonist Design
por: Huang, Gilbert Y., et al.
Publicado: (2014)

Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation
por: Scholler, Pauline, et al.
Publicado: (2017)

Non-covalent allosteric regulation of capsule catalysis
por: Martí-Centelles, Vicente, et al.
Publicado: (2020)

Substrate Binding Stiffens Aspartate Aminotransferase by Altering the Enzyme Picosecond Vibrational Dynamics
por: Dajnowicz, Steven, et al.
Publicado: (2020)

Probing the Druggablility on the Interface of the Protein–Protein Interaction and Its Allosteric Regulation Mechanism on the Drug Screening for the CXCR4 Homodimer
por: Shen, Liting, et al.
Publicado: (2019)

Identification of new allosteric sites and modulators of AChE through computational and experimental tools
por: Roca, Carlos, et al.
Publicado: (2018)

Covalent‐Allosteric Inhibitors to Achieve Akt Isoform‐Selectivity
por: Quambusch, Lena, et al.
Publicado: (2019)

Systematic Analysis of Covalent and Allosteric Protein Kinase Inhibitors
por: Xerxa, Elena, et al.
Publicado: (2023)

Metal-Free cAMP-Dependent Protein Kinase Can Catalyze Phosphoryl Transfer
por: Gerlits, Oksana, et al.
Publicado: (2014)

Allosteric interactions across native adenosine-A(3) receptor homodimers: quantification using single-cell ligand-binding kinetics
por: May, Lauren T., et al.
Publicado: (2011)

Xanomeline displays concomitant orthosteric and allosteric binding modes at the M(4) mAChR
por: Burger, Wessel A. C., et al.
Publicado: (2023)

Aryloxyalkanoic Acids as Non-Covalent Modifiers of the Allosteric Properties of Hemoglobin
por: Omar, Abdelsattar M., et al.
Publicado: (2016)

Revealing protonation states and tracking substrate in serine hydroxymethyltransferase with room-temperature X-ray and neutron crystallography
por: Drago, Victoria N., et al.
Publicado: (2023)

Types of interfaces for homodimer folding and binding
por: Karthikraja, Velmurugan, et al.
Publicado: (2009)

Ligand induced dissociation of the AR homodimer precedes AR monomer translocation to the nucleus
por: Shizu, Ryota, et al.
Publicado: (2019)

Selective glycoprotein detection through covalent templating and allosteric click-imprinting
por: Stephenson-Brown, Alexander, et al.
Publicado: (2015)

Structural and chemical insights into the covalent-allosteric inhibition of the protein kinase Akt
por: Uhlenbrock, Niklas, et al.
Publicado: (2019)

The current agonists and positive allosteric modulators of α7 nAChR for CNS indications in clinical trials
por: Yang, Taoyi, et al.
Publicado: (2017)

Semisynthetic Analogues of Toxiferine I and Their Pharmacological Properties at α7 nAChRs, Muscle-Type nAChRs, and the Allosteric Binding Site of Muscarinic M(2) Receptors
por: Zlotos, Darius P., et al.
Publicado: (2014)

Protein subunit interfaces: heterodimers versus homodimers
por: Zhanhua, Cui, et al.
Publicado: (2005)

Side chain flexibility and the symmetry of protein homodimers
por: Shalit, Yaffa, et al.
Publicado: (2020)

Global mapping of RNA homodimers in living cells
por: Gabryelska, Marta M., et al.
Publicado: (2022)

Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases
por: Andersen, Jacob Lauwring, et al.
Publicado: (2018)

Covalent Allosteric Inhibitors of Akt Generated Using a Click Fragment Approach
por: van der Westhuizen, Leandi, et al.
Publicado: (2022)

Levels of anxiety, depression and stress among health care workers during the COVID19 pandemic: Study conducted at the University Hospital Farhat Hached of Sousse-Tunisia
por: Belhadj Chabbah, N., et al.
Publicado: (2023)

Organophosphate Hydrolase in Conductometric Biosensor for the Detection of Organophosphate Pesticides
por: Mulyasuryani, Ani, et al.
Publicado: (2015)

The Allosteric Activation of α7 nAChR by α-Conotoxin MrIC Is Modified by Mutations at the Vestibular Site
por: Gulsevin, Alican, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_0k4c322hina4tkkk3pf6urjpos