Deciphering ion transport and ATPase coupling in the intersubunit tunnel of KdpFABC

KdpFABC, a high-affinity K(+) pump, combines the ion channel KdpA and the P-type ATPase KdpB to secure survival at K(+) limitation. Here, we apply a combination of cryo-EM, biochemical assays, and MD simulations to illuminate the mechanisms underlying transport and the coupling to ATP hydrolysis. We...

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Detalles Bibliográficos
Autores principales: Silberberg, Jakob M., Corey, Robin A., Hielkema, Lisa, Stock, Charlott, Stansfeld, Phillip J., Paulino, Cristina, Hänelt, Inga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8385062/
https://www.ncbi.nlm.nih.gov/pubmed/34429416
http://dx.doi.org/10.1038/s41467-021-25242-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8385062/
https://www.ncbi.nlm.nih.gov/pubmed/34429416
http://dx.doi.org/10.1038/s41467-021-25242-x

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