Deficiency of Axl aggravates pulmonary arterial hypertension via BMPR2

Pulmonary arterial hypertension (PAH), is a fatal disease characterized by a pseudo-malignant phenotype. We investigated the expression and the role of the receptor tyrosine kinase Axl in experimental (i.e., monocrotaline and Su5416/hypoxia treated rats) and clinical PAH. In vitro Axl inhibition by...

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Detalles Bibliográficos
Autores principales: Novoyatleva, Tatyana, Rai, Nabham, Kojonazarov, Baktybek, Veeroju, Swathi, Ben-Batalla, Isabel, Caruso, Paola, Shihan, Mazen, Presser, Nadine, Götz, Elsa, Lepper, Carina, Herpel, Sebastian, Manaud, Grégoire, Perros, Frédéric, Gall, Henning, Ghofrani, Hossein Ardeschir, Weissmann, Norbert, Grimminger, Friedrich, Wharton, John, Wilkins, Martin, Upton, Paul D., Loges, Sonja, Morrell, Nicholas W., Seeger, Werner, Schermuly, Ralph T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8385080/
https://www.ncbi.nlm.nih.gov/pubmed/34429509
http://dx.doi.org/10.1038/s42003-021-02531-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8385080/
https://www.ncbi.nlm.nih.gov/pubmed/34429509
http://dx.doi.org/10.1038/s42003-021-02531-1

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