A computational approach for identification of core modules from a co-expression network and GWAS data

This protocol describes the application of the “omnigenic” model of the genetic architecture of complex traits to identify novel “core” genes influencing a disease-associated phenotype. Core genes are hypothesized to directly regulate disease and may serve as therapeutic targets. This protocol lever...

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Detalles Bibliográficos
Autores principales: Sabik, Olivia L., Ackert-Bicknell, Cheryl L., Farber, Charles R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8385446/
https://www.ncbi.nlm.nih.gov/pubmed/34467232
http://dx.doi.org/10.1016/j.xpro.2021.100768

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8385446/
https://www.ncbi.nlm.nih.gov/pubmed/34467232
http://dx.doi.org/10.1016/j.xpro.2021.100768

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