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Evaluation of the Lipid-binding Properties of Recombinant Dystrophin Spectrin-like Repeat Domains R1-3

Recombinant micro-dystrophin genes are designed to treat Duchenne muscular dystrophy (DMD) by retaining dystrophin domains believed to play key functional roles while fitting the packaging capacity of adeno-associated virus vectors. Domains R1-3 are important for muscle force generation and for asso...

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Detalles Bibliográficos
Autores principales: Cooper-Olson, Grace, Rodino-Klapac, Louise R., Potter, Rachael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8385511/
https://www.ncbi.nlm.nih.gov/pubmed/33780374
http://dx.doi.org/10.3233/JND-200622