Selective FPR2 Agonism Promotes a Proresolution Macrophage Phenotype and Improves Cardiac Structure-Function Post Myocardial Infarction

Dysregulated inflammation following myocardial infarction (MI) leads to maladaptive healing and remodeling. The study characterized and evaluated a selective formyl peptide receptor 2 (FPR2) agonist BMS-986235 in cellular assays and in rodents undergoing MI. BMS-986235 activated G proteins and promo...

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Detalles Bibliográficos
Autores principales: García, Ricardo A., Lupisella, John A., Ito, Bruce R., Hsu, Mei-Yin, Fernando, Gayani, Carson, Nancy L., Allocco, John J., Ryan, Carol S., Zhang, Rongan, Wang, Zhaoqing, Heroux, Madeleine, Carrier, Marilyn, St.-Onge, Stéphane, Bouvier, Michel, Dudhgaonkar, Shailesh, Nagar, Jignesh, Bustamante-Pozo, Moises M., Garate-Carrillo, Alejandra, Chen, Jian, Ma, Xiuying, Search, Debra J., Dierks, Elizabeth A., Kick, Ellen K., Wexler, Ruth R., Gordon, David A., Ostrowski, Jacek, Wurtz, Nicholas R., Villarreal, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Preclinical Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8385569/
https://www.ncbi.nlm.nih.gov/pubmed/34466754
http://dx.doi.org/10.1016/j.jacbts.2021.07.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8385569/
https://www.ncbi.nlm.nih.gov/pubmed/34466754
http://dx.doi.org/10.1016/j.jacbts.2021.07.007

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