Characterization of SARS2 Nsp15 nuclease activity reveals it's mad about U

Nsp15 is a uridine specific endoribonuclease that coronaviruses employ to cleave viral RNA and evade host immune defense systems. Previous structures of Nsp15 from across Coronaviridae revealed that Nsp15 assembles into a homo-hexamer and has a conserved active site similar to RNase A. Beyond a pref...

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Detalles Bibliográficos
Autores principales: Frazier, Meredith N, Dillard, Lucas B, Krahn, Juno M, Perera, Lalith, Williams, Jason G, Wilson, Isha M, Stewart, Zachary D, Pillon, Monica C, Deterding, Leesa J, Borgnia, Mario J, Stanley, Robin E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8385992/
https://www.ncbi.nlm.nih.gov/pubmed/34403466
http://dx.doi.org/10.1093/nar/gkab719

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8385992/
https://www.ncbi.nlm.nih.gov/pubmed/34403466
http://dx.doi.org/10.1093/nar/gkab719

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