Molecular signatures of aggressive pediatric liver cancer

1. Conversion of tumor suppressor proteins (TSPs) by posttranslational modifications into oncogenes. 2. Activation of specific chromosomal regions, i.e., Aggressive Liver Cancer Domains (ALCDs) within many oncogenes, resulting in increased expression of oncogenes. 3. Potential epigenetic mechanisms...

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Detalles Bibliográficos
Autores principales: Johnston, Michael E., Timchenko, Nikolai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8386353/
https://www.ncbi.nlm.nih.gov/pubmed/34447970
Descripción
Sumario:1. Conversion of tumor suppressor proteins (TSPs) by posttranslational modifications into oncogenes. 2. Activation of specific chromosomal regions, i.e., Aggressive Liver Cancer Domains (ALCDs) within many oncogenes, resulting in increased expression of oncogenes. 3. Potential epigenetic mechanisms that open chromatin structure of oncogenes via ALCDs. This commentary summarizes our key findings and discusses development of potential ALCD-based therapeutic approaches.

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