Molecular signatures of aggressive pediatric liver cancer

1. Conversion of tumor suppressor proteins (TSPs) by posttranslational modifications into oncogenes. 2. Activation of specific chromosomal regions, i.e., Aggressive Liver Cancer Domains (ALCDs) within many oncogenes, resulting in increased expression of oncogenes. 3. Potential epigenetic mechanisms...

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Detalles Bibliográficos
Autores principales: Johnston, Michael E., Timchenko, Nikolai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8386353/
https://www.ncbi.nlm.nih.gov/pubmed/34447970
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author Johnston, Michael E.
Timchenko, Nikolai
author_facet Johnston, Michael E.
Timchenko, Nikolai
author_sort Johnston, Michael E.
collection PubMed
description 1. Conversion of tumor suppressor proteins (TSPs) by posttranslational modifications into oncogenes. 2. Activation of specific chromosomal regions, i.e., Aggressive Liver Cancer Domains (ALCDs) within many oncogenes, resulting in increased expression of oncogenes. 3. Potential epigenetic mechanisms that open chromatin structure of oncogenes via ALCDs. This commentary summarizes our key findings and discusses development of potential ALCD-based therapeutic approaches.
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spelling pubmed-83863532021-08-25 Molecular signatures of aggressive pediatric liver cancer Johnston, Michael E. Timchenko, Nikolai Arch Stem Cell Ther Article 1. Conversion of tumor suppressor proteins (TSPs) by posttranslational modifications into oncogenes. 2. Activation of specific chromosomal regions, i.e., Aggressive Liver Cancer Domains (ALCDs) within many oncogenes, resulting in increased expression of oncogenes. 3. Potential epigenetic mechanisms that open chromatin structure of oncogenes via ALCDs. This commentary summarizes our key findings and discusses development of potential ALCD-based therapeutic approaches. 2021 /pmc/articles/PMC8386353/ /pubmed/34447970 Text en https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Johnston, Michael E.
Timchenko, Nikolai
Molecular signatures of aggressive pediatric liver cancer
title Molecular signatures of aggressive pediatric liver cancer
title_full Molecular signatures of aggressive pediatric liver cancer
title_fullStr Molecular signatures of aggressive pediatric liver cancer
title_full_unstemmed Molecular signatures of aggressive pediatric liver cancer
title_short Molecular signatures of aggressive pediatric liver cancer
title_sort molecular signatures of aggressive pediatric liver cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8386353/
https://www.ncbi.nlm.nih.gov/pubmed/34447970
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