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A Transferable IncC-IncX3 Hybrid Plasmid Cocarrying bla(NDM-4), tet(X), and tmexCD3-toprJ3 Confers Resistance to Carbapenem and Tigecycline

Tigecycline is a last-resort antimicrobial against carbapenemase-producing Enterobacterales (CPE). However, mobile tigecycline resistance genes, tet(X) and tmexCD-toprJ, have emerged in China and have spread possibly worldwide. Tet(X) family proteins function as tigecycline-inactivating enzymes, and...

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Detalles Bibliográficos
Autores principales: Hirabayashi, Aki, Dao, Trung Duc, Takemura, Taichiro, Hasebe, Futoshi, Trang, Le Thi, Thanh, Nguyen Ha, Tran, Hoang Huy, Shibayama, Keigo, Kasuga, Ikuro, Suzuki, Masato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8386453/
https://www.ncbi.nlm.nih.gov/pubmed/34346701
http://dx.doi.org/10.1128/mSphere.00592-21