A pan-cancer analysis revealed the role of the SLC16 family in cancer
Cancer is one of the serious diseases that endanger human health and bring a heavy burden to world economic development. Although the current targeted therapy and immunotherapy have achieved initial results, the emergence of drug resistance shows that the existing research is far from enough. In rec...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8386723/ https://www.ncbi.nlm.nih.gov/pubmed/34424811 http://dx.doi.org/10.1080/19336950.2021.1965422 |
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author | Li, Jun Xie, Jiaheng Wu, Dan Chen, Liang Gong, Zetian Wu, Rui Hu, Yiming Zhao, Jiangning Xu, Yetao |
author_facet | Li, Jun Xie, Jiaheng Wu, Dan Chen, Liang Gong, Zetian Wu, Rui Hu, Yiming Zhao, Jiangning Xu, Yetao |
author_sort | Li, Jun |
collection | PubMed |
description | Cancer is one of the serious diseases that endanger human health and bring a heavy burden to world economic development. Although the current targeted therapy and immunotherapy have achieved initial results, the emergence of drug resistance shows that the existing research is far from enough. In recent years, the tumor microenvironment has been found to be an important condition for tumor development and has profound research value. The SLC16 family is a group of monocarboxylic acid transporters involved in cancer metabolism and the formation of the tumor microenvironment. However, there have been no generalized cancer studies in the SLC16 family. In this study, we conducted a pan-cancer analysis of the SLC16 family. The results showed that multiple members of the SLC16 family could be used as prognostic indicators for many tumors, and were associated with immune invasion and tumor stem cells. Therefore, the SLC16 family has extensive exploration value in the future. |
format | Online Article Text |
id | pubmed-8386723 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-83867232021-08-25 A pan-cancer analysis revealed the role of the SLC16 family in cancer Li, Jun Xie, Jiaheng Wu, Dan Chen, Liang Gong, Zetian Wu, Rui Hu, Yiming Zhao, Jiangning Xu, Yetao Channels (Austin) Research Paper Cancer is one of the serious diseases that endanger human health and bring a heavy burden to world economic development. Although the current targeted therapy and immunotherapy have achieved initial results, the emergence of drug resistance shows that the existing research is far from enough. In recent years, the tumor microenvironment has been found to be an important condition for tumor development and has profound research value. The SLC16 family is a group of monocarboxylic acid transporters involved in cancer metabolism and the formation of the tumor microenvironment. However, there have been no generalized cancer studies in the SLC16 family. In this study, we conducted a pan-cancer analysis of the SLC16 family. The results showed that multiple members of the SLC16 family could be used as prognostic indicators for many tumors, and were associated with immune invasion and tumor stem cells. Therefore, the SLC16 family has extensive exploration value in the future. Taylor & Francis 2021-08-23 /pmc/articles/PMC8386723/ /pubmed/34424811 http://dx.doi.org/10.1080/19336950.2021.1965422 Text en © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Paper Li, Jun Xie, Jiaheng Wu, Dan Chen, Liang Gong, Zetian Wu, Rui Hu, Yiming Zhao, Jiangning Xu, Yetao A pan-cancer analysis revealed the role of the SLC16 family in cancer |
title | A pan-cancer analysis revealed the role of the SLC16 family in cancer |
title_full | A pan-cancer analysis revealed the role of the SLC16 family in cancer |
title_fullStr | A pan-cancer analysis revealed the role of the SLC16 family in cancer |
title_full_unstemmed | A pan-cancer analysis revealed the role of the SLC16 family in cancer |
title_short | A pan-cancer analysis revealed the role of the SLC16 family in cancer |
title_sort | pan-cancer analysis revealed the role of the slc16 family in cancer |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8386723/ https://www.ncbi.nlm.nih.gov/pubmed/34424811 http://dx.doi.org/10.1080/19336950.2021.1965422 |
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