Genomic gain of RRS1 promotes hepatocellular carcinoma through reducing the RPL11-MDM2-p53 signaling

Hepatocellular carcinomas (HCCs) are characterized by frequent somatic genomic copy number alterations (CNAs), with most of them biologically unexplored. Here, we performed integrative analyses combining CNAs with the transcriptomic data to reveal the cis- and trans-effects of CNAs in HCC. We identi...

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Detalles Bibliográficos
Autores principales: Cao, Pengbo, Yang, Aiqing, Li, Peiyao, Xia, Xia, Han, Yuqing, Zhou, Guangming, Wang, Rui, Yang, Fei, Li, Yuanfeng, Zhang, Ying, Cui, Ying, Ji, Hongzan, Lu, Lei, He, Fuchu, Zhou, Gangqiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8386927/
https://www.ncbi.nlm.nih.gov/pubmed/34433556
http://dx.doi.org/10.1126/sciadv.abf4304

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8386927/
https://www.ncbi.nlm.nih.gov/pubmed/34433556
http://dx.doi.org/10.1126/sciadv.abf4304

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