A cancer ubiquitome landscape identifies metabolic reprogramming as target of Parkin tumor suppression

Changes in metabolism that affect mitochondrial and glycolytic networks are hallmarks of cancer, but their impact in disease is still elusive. Using global proteomics and ubiquitome screens, we now show that Parkin, an E3 ubiquitin ligase and key effector of mitophagy altered in Parkinson’s disease,...

Descripción completa

Detalles Bibliográficos
Autores principales: Agarwal, Ekta, Goldman, Aaron R., Tang, Hsin-Yao, Kossenkov, Andrew V., Ghosh, Jagadish C., Languino, Lucia R., Vaira, Valentina, Speicher, David W., Altieri, Dario C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8386929/
https://www.ncbi.nlm.nih.gov/pubmed/34433563
http://dx.doi.org/10.1126/sciadv.abg7287

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8386929/
https://www.ncbi.nlm.nih.gov/pubmed/34433563
http://dx.doi.org/10.1126/sciadv.abg7287

Ejemplares similares