HBO1-MLL interaction promotes AF4/ENL/P-TEFb-mediated leukemogenesis

Leukemic oncoproteins cause uncontrolled self-renewal of hematopoietic progenitors by aberrant gene activation, eventually causing leukemia. However, the molecular mechanism underlying aberrant gene activation remains elusive. Here, we showed that leukemic MLL fusion proteins associate with the HBO1...

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Detalles Bibliográficos
Autores principales: Takahashi, Satoshi, Kanai, Akinori, Okuda, Hiroshi, Miyamoto, Ryo, Komata, Yosuke, Kawamura, Takeshi, Matsui, Hirotaka, Inaba, Toshiya, Takaori-Kondo, Akifumi, Yokoyama, Akihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387021/
https://www.ncbi.nlm.nih.gov/pubmed/34431785
http://dx.doi.org/10.7554/eLife.65872

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387021/
https://www.ncbi.nlm.nih.gov/pubmed/34431785
http://dx.doi.org/10.7554/eLife.65872

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