Cargando…
Proliferative stem cells maintain quiescence of their niche by secreting the Activin inhibitor Follistatin
Aging causes stem cell dysfunction as a result of extrinsic and intrinsic changes. Decreased function of the stem cell niche is an important contributor to this dysfunction. We use the Drosophila testis to investigate what factors maintain niche cells. The testis niche comprises quiescent “hub” cell...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387025/ https://www.ncbi.nlm.nih.gov/pubmed/34363758 http://dx.doi.org/10.1016/j.devcel.2021.07.010 |
_version_ | 1783742374947586048 |
---|---|
author | Herrera, Salvador C. Sainz de la Maza, Diego Grmai, Lydia Margolis, Shally Plessel, Rebecca Burel, Michael O’Connor, Michael Amoyel, Marc Bach, Erika A. |
author_facet | Herrera, Salvador C. Sainz de la Maza, Diego Grmai, Lydia Margolis, Shally Plessel, Rebecca Burel, Michael O’Connor, Michael Amoyel, Marc Bach, Erika A. |
author_sort | Herrera, Salvador C. |
collection | PubMed |
description | Aging causes stem cell dysfunction as a result of extrinsic and intrinsic changes. Decreased function of the stem cell niche is an important contributor to this dysfunction. We use the Drosophila testis to investigate what factors maintain niche cells. The testis niche comprises quiescent “hub” cells and supports two mitotic stem cell pools: germline stem cells and somatic cyst stem cells (CySCs). We identify the cell-cycle-responsive Dp/E2f1 transcription factor as a crucial non-autonomous regulator required in CySCs to maintain hub cell quiescence. Dp/E2f1 inhibits local Activin ligands through production of the Activin antagonist Follistatin (Fs). Inactivation of Dp/E2f1 or Fs in CySCs or promoting Activin receptor signaling in hub cells causes transdifferentiation of hub cells into fully functional CySCs. This Activin-dependent communication between CySCs and hub regulates the physiological decay of the niche with age and demonstrates that hub cell quiescence results from signals from surrounding stem cells. |
format | Online Article Text |
id | pubmed-8387025 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Cell Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-83870252021-08-31 Proliferative stem cells maintain quiescence of their niche by secreting the Activin inhibitor Follistatin Herrera, Salvador C. Sainz de la Maza, Diego Grmai, Lydia Margolis, Shally Plessel, Rebecca Burel, Michael O’Connor, Michael Amoyel, Marc Bach, Erika A. Dev Cell Article Aging causes stem cell dysfunction as a result of extrinsic and intrinsic changes. Decreased function of the stem cell niche is an important contributor to this dysfunction. We use the Drosophila testis to investigate what factors maintain niche cells. The testis niche comprises quiescent “hub” cells and supports two mitotic stem cell pools: germline stem cells and somatic cyst stem cells (CySCs). We identify the cell-cycle-responsive Dp/E2f1 transcription factor as a crucial non-autonomous regulator required in CySCs to maintain hub cell quiescence. Dp/E2f1 inhibits local Activin ligands through production of the Activin antagonist Follistatin (Fs). Inactivation of Dp/E2f1 or Fs in CySCs or promoting Activin receptor signaling in hub cells causes transdifferentiation of hub cells into fully functional CySCs. This Activin-dependent communication between CySCs and hub regulates the physiological decay of the niche with age and demonstrates that hub cell quiescence results from signals from surrounding stem cells. Cell Press 2021-08-23 /pmc/articles/PMC8387025/ /pubmed/34363758 http://dx.doi.org/10.1016/j.devcel.2021.07.010 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Herrera, Salvador C. Sainz de la Maza, Diego Grmai, Lydia Margolis, Shally Plessel, Rebecca Burel, Michael O’Connor, Michael Amoyel, Marc Bach, Erika A. Proliferative stem cells maintain quiescence of their niche by secreting the Activin inhibitor Follistatin |
title | Proliferative stem cells maintain quiescence of their niche by secreting the Activin inhibitor Follistatin |
title_full | Proliferative stem cells maintain quiescence of their niche by secreting the Activin inhibitor Follistatin |
title_fullStr | Proliferative stem cells maintain quiescence of their niche by secreting the Activin inhibitor Follistatin |
title_full_unstemmed | Proliferative stem cells maintain quiescence of their niche by secreting the Activin inhibitor Follistatin |
title_short | Proliferative stem cells maintain quiescence of their niche by secreting the Activin inhibitor Follistatin |
title_sort | proliferative stem cells maintain quiescence of their niche by secreting the activin inhibitor follistatin |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387025/ https://www.ncbi.nlm.nih.gov/pubmed/34363758 http://dx.doi.org/10.1016/j.devcel.2021.07.010 |
work_keys_str_mv | AT herrerasalvadorc proliferativestemcellsmaintainquiescenceoftheirnichebysecretingtheactivininhibitorfollistatin AT sainzdelamazadiego proliferativestemcellsmaintainquiescenceoftheirnichebysecretingtheactivininhibitorfollistatin AT grmailydia proliferativestemcellsmaintainquiescenceoftheirnichebysecretingtheactivininhibitorfollistatin AT margolisshally proliferativestemcellsmaintainquiescenceoftheirnichebysecretingtheactivininhibitorfollistatin AT plesselrebecca proliferativestemcellsmaintainquiescenceoftheirnichebysecretingtheactivininhibitorfollistatin AT burelmichael proliferativestemcellsmaintainquiescenceoftheirnichebysecretingtheactivininhibitorfollistatin AT oconnormichael proliferativestemcellsmaintainquiescenceoftheirnichebysecretingtheactivininhibitorfollistatin AT amoyelmarc proliferativestemcellsmaintainquiescenceoftheirnichebysecretingtheactivininhibitorfollistatin AT bacherikaa proliferativestemcellsmaintainquiescenceoftheirnichebysecretingtheactivininhibitorfollistatin |