Heparan Sulfated Glypican-4 Is Released from Astrocytes by Proteolytic Shedding and GPI-Anchor Cleavage Mechanisms

Astrocytes provide neurons with diffusible factors that promote synapse formation and maturation. In particular, glypican-4/GPC4 released from astrocytes promotes the maturation of excitatory synapses. Unlike other secreted factors, GPC4 contains the C-terminal GPI-anchorage signal. However, the mec...

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Detalles Bibliográficos
Autores principales: Huang, Kevin, Park, Sungjin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2021
Materias:
Research Article: New Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387153/
https://www.ncbi.nlm.nih.gov/pubmed/34301723
http://dx.doi.org/10.1523/ENEURO.0069-21.2021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387153/
https://www.ncbi.nlm.nih.gov/pubmed/34301723
http://dx.doi.org/10.1523/ENEURO.0069-21.2021

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