SCD Inhibition Protects from α-Synuclein-Induced Neurotoxicity But Is Toxic to Early Neuron Cultures

Here, we report the independent discovery and validation of stearoyl-CoA desaturase (SCD) as a modulator of α-synuclein (αSyn)-induced pathology and toxicity in cell-based Parkinson’s disease (PD) models. We identified SCD as top altered gene from transcriptional profiling in primary neurons exogeno...

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Detalles Bibliográficos
Autores principales: Nicholatos, Justin W., Groot, Joost, Dhokai, Shekhar, Tran, David, Hrdlicka, Lori, Carlile, Thomas M., Bennion, Melissa, Dalkilic-Liddle, Isin, Hirst, Warren D., Weihofen, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2021
Materias:
Research Article: New Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387157/
https://www.ncbi.nlm.nih.gov/pubmed/34301719
http://dx.doi.org/10.1523/ENEURO.0166-21.2021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387157/
https://www.ncbi.nlm.nih.gov/pubmed/34301719
http://dx.doi.org/10.1523/ENEURO.0166-21.2021

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