Doxazosin Attenuates Liver Fibrosis by Inhibiting Autophagy in Hepatic Stellate Cells via Activation of the PI3K/Akt/mTOR Signaling Pathway

PURPOSE: To investigate the effect of doxazosin on autophagy and the activation of hepatic stellate cells (HSCs) in vivo and in vitro and determine the underlying mechanism. METHODS: In vivo, a mouse liver fibrosis model was induced by the intraperitoneal injection of carbon tetrachloride (CCl(4))....

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Detalles Bibliográficos
Autores principales: Xiu, Ai-Yuan, Ding, Qian, Li, Zhen, Zhang, Chun-Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387324/
https://www.ncbi.nlm.nih.gov/pubmed/34456560
http://dx.doi.org/10.2147/DDDT.S317701

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387324/
https://www.ncbi.nlm.nih.gov/pubmed/34456560
http://dx.doi.org/10.2147/DDDT.S317701

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