Serpin neuropathology in the P497S UBQLN2 mouse model of ALS/FTD

Accumulating evidence suggests X‐linked dominant mutations in UBQLN2 cause amyotrophic lateral sclerosis (ALS) with frontotemporal dementia (FTD) through both loss‐ and gain‐of‐function mechanisms. However, the mechanisms by which the mutations cause disease are still unclear. The goal of the study...

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Detalles Bibliográficos
Autores principales: Higgins, Nicole R., Greenslade, Jessie E., Wu, Josephine J., Miranda, Elena, Galliciotti, Giovanna, Monteiro, Mervyn J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387369/
https://www.ncbi.nlm.nih.gov/pubmed/33780087
http://dx.doi.org/10.1111/bpa.12948

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387369/
https://www.ncbi.nlm.nih.gov/pubmed/33780087
http://dx.doi.org/10.1111/bpa.12948

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