Enhanced CD4(+) and CD8(+) T cell infiltrate within convex hull defined pancreatic islet borders as autoimmune diabetes progresses

The notion that T cell insulitis increases as type 1 diabetes (T1D) develops is unsurprising, however, the quantitative analysis of CD4(+) and CD8(+) T cells within the islet mass is complex and limited with standard approaches. Optical microscopy is an important and widely used method to evaluate i...

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Detalles Bibliográficos
Autores principales: Dwyer, Alexander J., Ritz, Jacob M., Mitchell, Jason S., Martinov, Tijana, Alkhatib, Mohannad, Silva, Nubia, Tucker, Christopher G., Fife, Brian T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387412/
https://www.ncbi.nlm.nih.gov/pubmed/34433860
http://dx.doi.org/10.1038/s41598-021-96327-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387412/
https://www.ncbi.nlm.nih.gov/pubmed/34433860
http://dx.doi.org/10.1038/s41598-021-96327-2

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