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Enhanced CD4(+) and CD8(+) T cell infiltrate within convex hull defined pancreatic islet borders as autoimmune diabetes progresses
The notion that T cell insulitis increases as type 1 diabetes (T1D) develops is unsurprising, however, the quantitative analysis of CD4(+) and CD8(+) T cells within the islet mass is complex and limited with standard approaches. Optical microscopy is an important and widely used method to evaluate i...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387412/ https://www.ncbi.nlm.nih.gov/pubmed/34433860 http://dx.doi.org/10.1038/s41598-021-96327-2 |