Distinct immune microenvironment profiles of therapeutic responders emerge in combined TGFβ/PD-L1 blockade-treated squamous cell carcinoma

Transforming growth factor beta (TGFβ) and programmed death-ligand 1 (PD-L1) are often overproduced in refractory squamous cell carcinoma (SCC). We examined spatial patterns of PD-L1(+) cells in mouse and human SCCs and found that PD-L1 was primarily expressed on infiltrating leukocytes. Although co...

Descripción completa

Detalles Bibliográficos
Autores principales: Strait, Alexander A., Woolaver, Rachel A., Hall, Spencer C., Young, Christian D., Karam, Sana D., Jimeno, Antonio, Lan, Yan, Raben, David, Wang, Jing H., Wang, Xiao-Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387430/
https://www.ncbi.nlm.nih.gov/pubmed/34433873
http://dx.doi.org/10.1038/s42003-021-02522-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387430/
https://www.ncbi.nlm.nih.gov/pubmed/34433873
http://dx.doi.org/10.1038/s42003-021-02522-2

Ejemplares similares