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Na(V)1.5 knockout in iPSCs: a novel approach to study Na(V)1.5 variants in a human cardiomyocyte environment
Cardiomyocytes derived from patient-specific induced pluripotent stem cells (iPSC-CMs) successfully reproduce the mechanisms of several channelopathies. However, this approach involve cell reprogramming from somatic tissue biopsies or genomic editing in healthy iPSCs for every mutation found and to...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387439/ https://www.ncbi.nlm.nih.gov/pubmed/34433864 http://dx.doi.org/10.1038/s41598-021-96474-6 |