Small molecule inhibition of ATM kinase increases CRISPR-Cas9 1-bp insertion frequency

Mutational outcomes following CRISPR-Cas9-nuclease cutting in mammalian cells have recently been shown to be predictable and, in certain cases, skewed toward single genotypes. However, the ability to control these outcomes remains limited, especially for 1-bp insertions, a common and therapeutically...

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Detalles Bibliográficos
Autores principales: Bermudez-Cabrera, Heysol C., Culbertson, Sannie, Barkal, Sammy, Holmes, Benjamin, Shen, Max W., Zhang, Sophia, Gifford, David K., Sherwood, Richard I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387472/
https://www.ncbi.nlm.nih.gov/pubmed/34433825
http://dx.doi.org/10.1038/s41467-021-25415-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387472/
https://www.ncbi.nlm.nih.gov/pubmed/34433825
http://dx.doi.org/10.1038/s41467-021-25415-8

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