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Small molecule inhibition of ATM kinase increases CRISPR-Cas9 1-bp insertion frequency
Mutational outcomes following CRISPR-Cas9-nuclease cutting in mammalian cells have recently been shown to be predictable and, in certain cases, skewed toward single genotypes. However, the ability to control these outcomes remains limited, especially for 1-bp insertions, a common and therapeutically...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387472/ https://www.ncbi.nlm.nih.gov/pubmed/34433825 http://dx.doi.org/10.1038/s41467-021-25415-8 |