Combined intermittent fasting and ERK inhibition enhance the anti-tumor effects of chemotherapy via the GSK3β-SIRT7 axis

Dietary interventions such as intermittent fasting (IF) have emerged as an attractive strategy for cancer therapies; therefore, understanding the underlying molecular mechanisms is pivotal. Here, we find SIRT7 decline markedly attenuates the anti-tumor effect of IF. Mechanistically, AMP-activated pr...

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Detalles Bibliográficos
Autores principales: Tang, Xiaolong, Li, Guo, Shi, Lei, Su, Fengting, Qian, Minxian, Liu, Zuojun, Meng, Yuan, Sun, Shimin, Li, Ji, Liu, Baohua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387475/
https://www.ncbi.nlm.nih.gov/pubmed/34433808
http://dx.doi.org/10.1038/s41467-021-25274-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387475/
https://www.ncbi.nlm.nih.gov/pubmed/34433808
http://dx.doi.org/10.1038/s41467-021-25274-3

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