A thiol-based intramolecular redox switch in four-repeat tau controls fibril assembly and disassembly

Oxidative stress has been implicated in the pathogenesis and progression of several tauopathies, including Alzheimer's disease. The deposition of fibrillar inclusions made of tau protein is one of the pathological hallmarks of these disorders. Although it is becoming increasingly evident that t...

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Detalles Bibliográficos
Autores principales: Weismiller, Hilary A., Holub, Tyler J., Krzesinski, Brad J., Margittai, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387771/
https://www.ncbi.nlm.nih.gov/pubmed/34339733
http://dx.doi.org/10.1016/j.jbc.2021.101021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387771/
https://www.ncbi.nlm.nih.gov/pubmed/34339733
http://dx.doi.org/10.1016/j.jbc.2021.101021

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