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A thiol-based intramolecular redox switch in four-repeat tau controls fibril assembly and disassembly
Oxidative stress has been implicated in the pathogenesis and progression of several tauopathies, including Alzheimer's disease. The deposition of fibrillar inclusions made of tau protein is one of the pathological hallmarks of these disorders. Although it is becoming increasingly evident that t...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387771/ https://www.ncbi.nlm.nih.gov/pubmed/34339733 http://dx.doi.org/10.1016/j.jbc.2021.101021 |