Partial Inhibition of the 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase-3 (PFKFB3) Enzyme in Myeloid Cells Does Not Affect Atherosclerosis

BACKGROUND: The protein 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) is a key stimulator of glycolytic flux. Systemic, partial PFKFB3 inhibition previously decreased total plaque burden and increased plaque stability. However, it is unclear which cell type conferred these positive...

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Detalles Bibliográficos
Autores principales: Tillie, Renée J. H. A., De Bruijn, Jenny, Perales-Patón, Javier, Temmerman, Lieve, Ghosheh, Yanal, Van Kuijk, Kim, Gijbels, Marion J., Carmeliet, Peter, Ley, Klaus, Saez-Rodriguez, Julio, Sluimer, Judith C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387953/
https://www.ncbi.nlm.nih.gov/pubmed/34458258
http://dx.doi.org/10.3389/fcell.2021.695684

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387953/
https://www.ncbi.nlm.nih.gov/pubmed/34458258
http://dx.doi.org/10.3389/fcell.2021.695684

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