Design and Synthesis of LM146, a Potent Inhibitor of PB1 with an Improved Selectivity Profile over SMARCA2

[Image: see text] PB1 is a bromodomain-containing protein hypothesized to act as the nucleosome-recognition subunit of the PBAF complex. Although PB1 is a key component of the PBAF chromatin remodeling complex, its exact role has not been elucidated due to the lack of potent and selective inhibitors...

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Detalles Bibliográficos
Autores principales: Mélin, Léa, Gesner, Emily, Attwell, Sarah, Kharenko, Olesya A., van der Horst, Edward H., Hansen, Henrik C., Gagnon, Alexandre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387997/
https://www.ncbi.nlm.nih.gov/pubmed/34471737
http://dx.doi.org/10.1021/acsomega.1c01555

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387997/
https://www.ncbi.nlm.nih.gov/pubmed/34471737
http://dx.doi.org/10.1021/acsomega.1c01555

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