Isobolographic analysis reveals antinociceptive synergism between Phα1β recombinant toxin and morphine in a model of cancer pain in C57BL/6J mice

BACKGROUND: Phoneutria nigriventer venom contains Phα1β. This toxin and its recombinant form have a remarkable analgesic potential that is associated with blockage of voltage-gated calcium channels and TRPA1 receptors. Although morphine is a mainstay drug to treat moderate and severe pain related to...

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Detalles Bibliográficos
Autores principales: Aoki, Caio Tavares, Moura, Rodrigo Andrade, Ferreira, Luana Assis, Mendes, Mariana Garcia, Santos, Duana Carvalho, Rezende, Marcio Junior, Gomez, Marcus Vinícius, Castro-Junior, Célio José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centro de Estudos de Venenos e Animais Peçonhentos 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8388195/
https://www.ncbi.nlm.nih.gov/pubmed/34512739
http://dx.doi.org/10.1590/1678-9199-JVATITD-2021-0027

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8388195/
https://www.ncbi.nlm.nih.gov/pubmed/34512739
http://dx.doi.org/10.1590/1678-9199-JVATITD-2021-0027

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