Perceptions of partial gland ablation for prostate cancer among men on active surveillance: a qualitative study

OBJECTIVES: Partial gland ablation (PGA) therapy is an emerging treatment modality that targets specific areas of biopsy-proven prostate cancer (PCa) to minimize treatment-related morbidity by sparing benign prostate. This qualitative study aims to explore and characterize perceptions and attitudes...

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Autores principales: Hur, Sonia, Tzeng, Michael, Cricco-Lizza, Eliza, Basourakos, Spyridon, Yu, Miko, Ancker, Jessica, Abramson, Erika, Saigal, Christopher, Ross, Ashley, Hu, Jim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8388575/
https://www.ncbi.nlm.nih.gov/pubmed/34458727
http://dx.doi.org/10.1136/bmjsit-2020-000068
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author Hur, Sonia
Tzeng, Michael
Cricco-Lizza, Eliza
Basourakos, Spyridon
Yu, Miko
Ancker, Jessica
Abramson, Erika
Saigal, Christopher
Ross, Ashley
Hu, Jim
author_facet Hur, Sonia
Tzeng, Michael
Cricco-Lizza, Eliza
Basourakos, Spyridon
Yu, Miko
Ancker, Jessica
Abramson, Erika
Saigal, Christopher
Ross, Ashley
Hu, Jim
author_sort Hur, Sonia
collection PubMed
description OBJECTIVES: Partial gland ablation (PGA) therapy is an emerging treatment modality that targets specific areas of biopsy-proven prostate cancer (PCa) to minimize treatment-related morbidity by sparing benign prostate. This qualitative study aims to explore and characterize perceptions and attitudes toward PGA in men with very-low-risk, low-risk, and favorable intermediate-risk PCa on active surveillance (AS). DESIGN: 92 men diagnosed with very-low-risk, low-risk, and favorable intermediate-risk PCa on AS were invited to participate in semistructured telephone interviews on PGA. SETTING: Single tertiary care center located in New York City. PARTICIPANTS: 20 men with very-low-risk, low-risk, and favorable intermediate-risk PCa on AS participated in the interviews. MAIN OUTCOME MEASURES: Emerging themes on perceptions and attitudes toward PGA were developed from transcripts inductively coded and analyzed under standardized methodology. RESULTS: Four themes were derived from 20 interviews that represent the primary considerations in treatment decision-making: (1) the feeling of psychological safety associated with low-risk disease; (2) preference for minimally invasive treatments; (3) the central role of the physician; (4) and the pursuit of treatment options that align with disease severity. Eleven men (55%) expressed interest in pursuing PGA only if their cancer were to progress, while nine men (45%) expressed interest at the current moment. CONCLUSIONS: Although an emerging treatment modality, patients were broadly accepting of PGA for PCa, with men primarily debating the risks versus benefits of proactively treating low-risk disease. Additional research on men’s preferences and attitudes toward PGA will further guide counseling and shared decision-making for PGA.
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spelling pubmed-83885752021-08-26 Perceptions of partial gland ablation for prostate cancer among men on active surveillance: a qualitative study Hur, Sonia Tzeng, Michael Cricco-Lizza, Eliza Basourakos, Spyridon Yu, Miko Ancker, Jessica Abramson, Erika Saigal, Christopher Ross, Ashley Hu, Jim BMJ Surg Interv Health Technol Original Research OBJECTIVES: Partial gland ablation (PGA) therapy is an emerging treatment modality that targets specific areas of biopsy-proven prostate cancer (PCa) to minimize treatment-related morbidity by sparing benign prostate. This qualitative study aims to explore and characterize perceptions and attitudes toward PGA in men with very-low-risk, low-risk, and favorable intermediate-risk PCa on active surveillance (AS). DESIGN: 92 men diagnosed with very-low-risk, low-risk, and favorable intermediate-risk PCa on AS were invited to participate in semistructured telephone interviews on PGA. SETTING: Single tertiary care center located in New York City. PARTICIPANTS: 20 men with very-low-risk, low-risk, and favorable intermediate-risk PCa on AS participated in the interviews. MAIN OUTCOME MEASURES: Emerging themes on perceptions and attitudes toward PGA were developed from transcripts inductively coded and analyzed under standardized methodology. RESULTS: Four themes were derived from 20 interviews that represent the primary considerations in treatment decision-making: (1) the feeling of psychological safety associated with low-risk disease; (2) preference for minimally invasive treatments; (3) the central role of the physician; (4) and the pursuit of treatment options that align with disease severity. Eleven men (55%) expressed interest in pursuing PGA only if their cancer were to progress, while nine men (45%) expressed interest at the current moment. CONCLUSIONS: Although an emerging treatment modality, patients were broadly accepting of PGA for PCa, with men primarily debating the risks versus benefits of proactively treating low-risk disease. Additional research on men’s preferences and attitudes toward PGA will further guide counseling and shared decision-making for PGA. BMJ Publishing Group 2021-04-21 /pmc/articles/PMC8388575/ /pubmed/34458727 http://dx.doi.org/10.1136/bmjsit-2020-000068 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Original Research
Hur, Sonia
Tzeng, Michael
Cricco-Lizza, Eliza
Basourakos, Spyridon
Yu, Miko
Ancker, Jessica
Abramson, Erika
Saigal, Christopher
Ross, Ashley
Hu, Jim
Perceptions of partial gland ablation for prostate cancer among men on active surveillance: a qualitative study
title Perceptions of partial gland ablation for prostate cancer among men on active surveillance: a qualitative study
title_full Perceptions of partial gland ablation for prostate cancer among men on active surveillance: a qualitative study
title_fullStr Perceptions of partial gland ablation for prostate cancer among men on active surveillance: a qualitative study
title_full_unstemmed Perceptions of partial gland ablation for prostate cancer among men on active surveillance: a qualitative study
title_short Perceptions of partial gland ablation for prostate cancer among men on active surveillance: a qualitative study
title_sort perceptions of partial gland ablation for prostate cancer among men on active surveillance: a qualitative study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8388575/
https://www.ncbi.nlm.nih.gov/pubmed/34458727
http://dx.doi.org/10.1136/bmjsit-2020-000068
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