Perceptions of partial gland ablation for prostate cancer among men on active surveillance: a qualitative study
OBJECTIVES: Partial gland ablation (PGA) therapy is an emerging treatment modality that targets specific areas of biopsy-proven prostate cancer (PCa) to minimize treatment-related morbidity by sparing benign prostate. This qualitative study aims to explore and characterize perceptions and attitudes...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8388575/ https://www.ncbi.nlm.nih.gov/pubmed/34458727 http://dx.doi.org/10.1136/bmjsit-2020-000068 |
_version_ | 1783742674017189888 |
---|---|
author | Hur, Sonia Tzeng, Michael Cricco-Lizza, Eliza Basourakos, Spyridon Yu, Miko Ancker, Jessica Abramson, Erika Saigal, Christopher Ross, Ashley Hu, Jim |
author_facet | Hur, Sonia Tzeng, Michael Cricco-Lizza, Eliza Basourakos, Spyridon Yu, Miko Ancker, Jessica Abramson, Erika Saigal, Christopher Ross, Ashley Hu, Jim |
author_sort | Hur, Sonia |
collection | PubMed |
description | OBJECTIVES: Partial gland ablation (PGA) therapy is an emerging treatment modality that targets specific areas of biopsy-proven prostate cancer (PCa) to minimize treatment-related morbidity by sparing benign prostate. This qualitative study aims to explore and characterize perceptions and attitudes toward PGA in men with very-low-risk, low-risk, and favorable intermediate-risk PCa on active surveillance (AS). DESIGN: 92 men diagnosed with very-low-risk, low-risk, and favorable intermediate-risk PCa on AS were invited to participate in semistructured telephone interviews on PGA. SETTING: Single tertiary care center located in New York City. PARTICIPANTS: 20 men with very-low-risk, low-risk, and favorable intermediate-risk PCa on AS participated in the interviews. MAIN OUTCOME MEASURES: Emerging themes on perceptions and attitudes toward PGA were developed from transcripts inductively coded and analyzed under standardized methodology. RESULTS: Four themes were derived from 20 interviews that represent the primary considerations in treatment decision-making: (1) the feeling of psychological safety associated with low-risk disease; (2) preference for minimally invasive treatments; (3) the central role of the physician; (4) and the pursuit of treatment options that align with disease severity. Eleven men (55%) expressed interest in pursuing PGA only if their cancer were to progress, while nine men (45%) expressed interest at the current moment. CONCLUSIONS: Although an emerging treatment modality, patients were broadly accepting of PGA for PCa, with men primarily debating the risks versus benefits of proactively treating low-risk disease. Additional research on men’s preferences and attitudes toward PGA will further guide counseling and shared decision-making for PGA. |
format | Online Article Text |
id | pubmed-8388575 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-83885752021-08-26 Perceptions of partial gland ablation for prostate cancer among men on active surveillance: a qualitative study Hur, Sonia Tzeng, Michael Cricco-Lizza, Eliza Basourakos, Spyridon Yu, Miko Ancker, Jessica Abramson, Erika Saigal, Christopher Ross, Ashley Hu, Jim BMJ Surg Interv Health Technol Original Research OBJECTIVES: Partial gland ablation (PGA) therapy is an emerging treatment modality that targets specific areas of biopsy-proven prostate cancer (PCa) to minimize treatment-related morbidity by sparing benign prostate. This qualitative study aims to explore and characterize perceptions and attitudes toward PGA in men with very-low-risk, low-risk, and favorable intermediate-risk PCa on active surveillance (AS). DESIGN: 92 men diagnosed with very-low-risk, low-risk, and favorable intermediate-risk PCa on AS were invited to participate in semistructured telephone interviews on PGA. SETTING: Single tertiary care center located in New York City. PARTICIPANTS: 20 men with very-low-risk, low-risk, and favorable intermediate-risk PCa on AS participated in the interviews. MAIN OUTCOME MEASURES: Emerging themes on perceptions and attitudes toward PGA were developed from transcripts inductively coded and analyzed under standardized methodology. RESULTS: Four themes were derived from 20 interviews that represent the primary considerations in treatment decision-making: (1) the feeling of psychological safety associated with low-risk disease; (2) preference for minimally invasive treatments; (3) the central role of the physician; (4) and the pursuit of treatment options that align with disease severity. Eleven men (55%) expressed interest in pursuing PGA only if their cancer were to progress, while nine men (45%) expressed interest at the current moment. CONCLUSIONS: Although an emerging treatment modality, patients were broadly accepting of PGA for PCa, with men primarily debating the risks versus benefits of proactively treating low-risk disease. Additional research on men’s preferences and attitudes toward PGA will further guide counseling and shared decision-making for PGA. BMJ Publishing Group 2021-04-21 /pmc/articles/PMC8388575/ /pubmed/34458727 http://dx.doi.org/10.1136/bmjsit-2020-000068 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Original Research Hur, Sonia Tzeng, Michael Cricco-Lizza, Eliza Basourakos, Spyridon Yu, Miko Ancker, Jessica Abramson, Erika Saigal, Christopher Ross, Ashley Hu, Jim Perceptions of partial gland ablation for prostate cancer among men on active surveillance: a qualitative study |
title | Perceptions of partial gland ablation for prostate cancer among men on active surveillance: a qualitative study |
title_full | Perceptions of partial gland ablation for prostate cancer among men on active surveillance: a qualitative study |
title_fullStr | Perceptions of partial gland ablation for prostate cancer among men on active surveillance: a qualitative study |
title_full_unstemmed | Perceptions of partial gland ablation for prostate cancer among men on active surveillance: a qualitative study |
title_short | Perceptions of partial gland ablation for prostate cancer among men on active surveillance: a qualitative study |
title_sort | perceptions of partial gland ablation for prostate cancer among men on active surveillance: a qualitative study |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8388575/ https://www.ncbi.nlm.nih.gov/pubmed/34458727 http://dx.doi.org/10.1136/bmjsit-2020-000068 |
work_keys_str_mv | AT hursonia perceptionsofpartialglandablationforprostatecanceramongmenonactivesurveillanceaqualitativestudy AT tzengmichael perceptionsofpartialglandablationforprostatecanceramongmenonactivesurveillanceaqualitativestudy AT criccolizzaeliza perceptionsofpartialglandablationforprostatecanceramongmenonactivesurveillanceaqualitativestudy AT basourakosspyridon perceptionsofpartialglandablationforprostatecanceramongmenonactivesurveillanceaqualitativestudy AT yumiko perceptionsofpartialglandablationforprostatecanceramongmenonactivesurveillanceaqualitativestudy AT anckerjessica perceptionsofpartialglandablationforprostatecanceramongmenonactivesurveillanceaqualitativestudy AT abramsonerika perceptionsofpartialglandablationforprostatecanceramongmenonactivesurveillanceaqualitativestudy AT saigalchristopher perceptionsofpartialglandablationforprostatecanceramongmenonactivesurveillanceaqualitativestudy AT rossashley perceptionsofpartialglandablationforprostatecanceramongmenonactivesurveillanceaqualitativestudy AT hujim perceptionsofpartialglandablationforprostatecanceramongmenonactivesurveillanceaqualitativestudy |