Non-β-Lactam Allosteric Inhibitors Target Methicillin-Resistant Staphylococcus aureus: An In Silico Drug Discovery Study

Penicillin-binding proteins (PBPs) catalyze the final stages for peptidoglycan cell-wall bio-synthesis. Mutations in the PBP2a subunit can attenuate β-lactam antibiotic activity, resulting in unimpeded cell-wall formation and methicillin-resistant Staphylococcus aureus (MRSA). A double mutation in P...

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Detalles Bibliográficos
Autores principales: Ibrahim, Mahmoud A. A., Abdeljawaad, Khlood A. A., Abdelrahman, Alaa H. M., Alzahrani, Othman R., Alshabrmi, Fahad M., Khalaf, Esraa, Moustafa, Mahmoud F., Alrumaihi, Faris, Allemailem, Khaled S., Soliman, Mahmoud E. S., Paré, Paul W., Hegazy, Mohamed-Elamir F., Atia, Mohamed A. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8388891/
https://www.ncbi.nlm.nih.gov/pubmed/34438984
http://dx.doi.org/10.3390/antibiotics10080934

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8388891/
https://www.ncbi.nlm.nih.gov/pubmed/34438984
http://dx.doi.org/10.3390/antibiotics10080934

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