Pterostilbene Increases LDL Metabolism in HL-1 Cardiomyocytes by Modulating the PCSK9/HNF1α/SREBP2/LDLR Signaling Cascade, Upregulating Epigenetic hsa-miR-335 and hsa-miR-6825, and LDL Receptor Expression

Proprotein convertase subtilisin/kexin type 9 (PCSK9) can promote the degradation of low-density lipoprotein (LDL) receptor (LDLR), leading to hypercholesterolemia and myocardial dysfunction. The intracellular regulatory mechanism by which the natural polyphenol pterostilbene modulates the PCSK9/LDL...

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Detalles Bibliográficos
Autores principales: Lin, Yen-Kuang, Yeh, Chi-Tai, Kuo, Kuang-Tai, Yadav, Vijesh Kumar, Fong, Iat-Hang, Kounis, Nicholas G., Hu, Patrick, Hung, Ming-Yow
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389247/
https://www.ncbi.nlm.nih.gov/pubmed/34439528
http://dx.doi.org/10.3390/antiox10081280

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389247/
https://www.ncbi.nlm.nih.gov/pubmed/34439528
http://dx.doi.org/10.3390/antiox10081280

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