Cargando…

Isoorientin Attenuated the Pyroptotic Hepatocyte Damage Induced by Benzo[a]pyrene via ROS/NF-κB/NLRP3/Caspase-1 Signaling Pathway

Isoorientin (Iso), a natural bioactive flavonoid, possesses significant anti-tumor and anti-oxidant activities. Benzo[a]pyrene (BaP) is a food processing injurant with carcinogenicity, teratogenicity, and genotoxicity. Our preliminary study demonstrates that Iso attenuated the pyroptotic hepatocyte...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Hao, Yuan, Li, Li, Xueyi, Luo, Ying, Zhang, Zhong, Li, Jianke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389279/ https://www.ncbi.nlm.nih.gov/pubmed/34439523 http://dx.doi.org/10.3390/antiox10081275

Ejemplares similares

Pyroptotic and non‐pyroptotic effector functions of caspase‐11
por: Abu Khweek, Arwa, et al.
Publicado: (2020)

Hydrogen inhibits endometrial cancer growth via a ROS/NLRP3/caspase-1/GSDMD-mediated pyroptotic pathway
por: Yang, Ye, et al.
Publicado: (2020)

Fibroblast growth factor 21 attenuates ventilator-induced lung injury by inhibiting the NLRP3/caspase-1/GSDMD pyroptotic pathway
por: Ding, Peng, et al.
Publicado: (2023)

P2X7 Receptor Induces Pyroptotic Inflammation and Cartilage Degradation in Osteoarthritis via NF-κB/NLRP3 Crosstalk
por: Li, Zihao, et al.
Publicado: (2021)

Leptin Induces Apoptotic and Pyroptotic Cell Death via NLRP3 Inflammasome Activation in Rat Hepatocytes
por: Baral, Ananda, et al.
Publicado: (2021)

Effects of Benzo[a]pyrene Exposure on Human Hepatocellular Carcinoma Cell Angiogenesis, Metastasis, and NF-κB Signaling
por: Ba, Qian, et al.
Publicado: (2014)

Burning, but Not Dying: the Failure of Pyroptotic Cell Death in Hepatocytes
por: Guicciardi, Maria Eugenia, et al.
Publicado: (2021)

Benzo[a]pyrene induces NLRP1 expression and promotes prolonged inflammasome signaling
por: Kohno, Risa, et al.
Publicado: (2023)

Tangshen Formula Attenuates Diabetic Kidney Injury by Imparting Anti-pyroptotic Effects via the TXNIP-NLRP3-GSDMD Axis
por: Li, Nan, et al.
Publicado: (2021)

NLRP3 deletion inhibits inflammation-driven mouse lung tumorigenesis induced by benzo(a)pyrene and lipopolysaccharide
por: Huang, Li, et al.
Publicado: (2019)

UVA Photoirradiation of Methylated Benzo[a]pyrene and Benzo[e]pyrene leading to Induction of Lipid Peroxidation
por: Sáenz, Diógenes Herreño, et al.
Publicado: (2007)

An Apoptotic Caspase Network Safeguards Cell Death Induction in Pyroptotic Macrophages
por: de Vasconcelos, Nathalia Moraes, et al.
Publicado: (2020)

Bacillus subtilis is a Potential Degrader of Pyrene and Benzo[a]pyrene
por: Hunter, Rochelle D., et al.
Publicado: (2005)

Blocking Caspase-1/Gsdmd and Caspase-3/-8/Gsdme pyroptotic pathways rescues silicosis in mice
por: Kang, Lulu, et al.
Publicado: (2022)

Micheliolide Attenuates Lipopolysaccharide-Induced Inflammation by Modulating the mROS/NF-κB/NLRP3 Axis in Renal Tubular Epithelial Cells
por: Lei, Xianghong, et al.
Publicado: (2020)

Isoorientin Inhibits Amyloid β(25–35)-Induced Neuronal Inflammation in BV2 Cells by Blocking the NF-κB Signaling Pathway
por: Kim, Buyun, et al.
Publicado: (2021)

Novel recombinant protein flagellin A N/C attenuates experimental autoimmune encephalomyelitis by suppressing the ROS/NF-κB/NLRP3 signaling pathway
por: Li, Li, et al.
Publicado: (2022)

Isoorientin ameliorates osteoporosis and oxidative stress in postmenopausal rats
por: Cao, Zhilin, et al.
Publicado: (2022)

Changes of biomarkers with oral exposure to benzo(a)pyrene, phenanthrene and pyrene in rats
por: Kang, Hwan Goo, et al.
Publicado: (2007)

ATOH8 promotes HBV immune tolerance by inhibiting the pyroptotic pathway in hepatocytes
por: Liu, Xiaofei, et al.
Publicado: (2023)

Punicalagin Attenuates LPS-Induced Inflammation and ROS Production in Microglia by Inhibiting the MAPK/NF-κB Signaling Pathway and NLRP3 Inflammasome Activation
por: Lo, Jung, et al.
Publicado: (2022)

Echovirus 11 infection induces pyroptotic cell death by facilitating NLRP3 inflammasome activation
por: Wang, Chong, et al.
Publicado: (2022)

Free radicals of benzo(a)pyrene and derivatives.
por: Sullivan, P D
Publicado: (1985)

ST2825, a Small Molecule Inhibitor of MyD88, Suppresses NF-κB Activation and the ROS/NLRP3/Cleaved Caspase-1 Signaling Pathway to Attenuate Lipopolysaccharide-Stimulated Neuroinflammation
por: Zhang, Shan-Shan, et al.
Publicado: (2022)

Scorpion Venom Antimicrobial Peptides Induce Caspase-1 Dependant Pyroptotic Cell Death
por: Elrayess, Ranwa A., et al.
Publicado: (2022)

Kindlin-2 inhibits TNF/NF-κB-Caspase 8 pathway in hepatocytes to maintain liver development and function
por: Gao, Huanqing, et al.
Publicado: (2023)

Biotransformation of benzo[a]pyrene by Pannonibacter sp. JPA3 and the degradation mechanism through the initially oxidized benzo[a]pyrene-4,5-dihydrodiol to downstream metabolites
por: Jin, Jingnan, et al.
Publicado: (2023)

Polyphyllin VI Induces Caspase-1-Mediated Pyroptosis via the Induction of ROS/NF-κB/NLRP3/GSDMD Signal Axis in Non-Small Cell Lung Cancer
por: Teng, Jin-Feng, et al.
Publicado: (2020)

HMGB1 promotes the activation of NLRP3 and caspase-8 inflammasomes via NF-κB pathway in acute glaucoma
por: Chi, Wei, et al.
Publicado: (2015)

Impact of Isoorientin on Metabolic Activity and Lipid Accumulation in Differentiated Adipocytes
por: Ziqubu, Khanyisani, et al.
Publicado: (2020)

Koumine Suppresses IL-1β Secretion and Attenuates Inflammation Associated With Blocking ROS/NF-κB/NLRP3 Axis in Macrophages
por: Luo, Yufei, et al.
Publicado: (2021)

Chlorophyll catalyse the photo-transformation of carcinogenic benzo[a]pyrene in water
por: Luo, Lijuan, et al.
Publicado: (2015)

Quantitation of exposure to benzo[a]pyrene with monoclonal antibodies.
por: Santella, R M, et al.
Publicado: (1985)

Influence of Benzo(a)pyrene on Different Epigenetic Processes
por: Bukowska, Bożena, et al.
Publicado: (2021)

Benzo[a]pyrene and Benzo[k]fluoranthene in Some Processed Fish and Fish Products
por: Olatunji, Olatunde S., et al.
Publicado: (2015)

Oridonin Prolongs the Survival of Mouse Cardiac Allografts by Attenuating the NF-κB/NLRP3 Pathway
por: Du, Xiaoxiao, et al.
Publicado: (2021)

Benzo(a)pyrene in Cigarette Smoke Enhances HIV-1 Replication through NF-κB Activation via CYP-Mediated Oxidative Stress Pathway
por: Ranjit, Sabina, et al.
Publicado: (2018)

Vibrio pore-forming leukocidin activates pyroptotic cell death via the NLRP3 inflammasome
por: Cohen, Hadar, et al.
Publicado: (2020)

Isoorientin Inhibits Inflammation in Macrophages and Endotoxemia Mice by Regulating Glycogen Synthase Kinase 3β
por: Li, Yingui, et al.
Publicado: (2020)

Anti-Rheumatic Properties of Gentiopicroside Are Associated With Suppression of ROS-NF-κB-NLRP3 Axis in Fibroblast-Like Synoviocytes and NF-κB Pathway in Adjuvant-Induced Arthritis
por: Wang, Meiling, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_dv4c4klks75q1evqtag3q1bapq