TRPM2 Non-Selective Cation Channels in Liver Injury Mediated by Reactive Oxygen Species

TRPM2 channels admit Ca(2+) and Na(+) across the plasma membrane and release Ca(2+) and Zn(2+) from lysosomes. Channel activation is initiated by reactive oxygen species (ROS), leading to a subsequent increase in ADP-ribose and the binding of ADP-ribose to an allosteric site in the cytosolic NUDT9 h...

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Detalles Bibliográficos
Autores principales: Ali, Eunus S., Rychkov, Grigori Y., Barritt, Greg J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389341/
https://www.ncbi.nlm.nih.gov/pubmed/34439491
http://dx.doi.org/10.3390/antiox10081243

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389341/
https://www.ncbi.nlm.nih.gov/pubmed/34439491
http://dx.doi.org/10.3390/antiox10081243

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