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Subanesthetic ketamine rapidly alters medial prefrontal miRNAs involved in ubiquitin-mediated proteolysis

Ketamine is a dissociative anesthetic and a non-competitive NMDAR antagonist. At subanesthetic dose, ketamine can relieve pain and work as a fast-acting antidepressant, but the underlying molecular mechanism remains elusive. This study aimed to investigate the mode of action underlying the effects o...

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Detalles Bibliográficos
Autores principales: Choi, Yunjung, Kim, Baeksun, Ham, Suji, Chung, Sooyoung, Maeng, Sungho, Kim, Hye-Sun, Im, Heh-In
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389495/
https://www.ncbi.nlm.nih.gov/pubmed/34437591
http://dx.doi.org/10.1371/journal.pone.0256390