Local Delivery of Pirfenidone by PLA Implants Modifies Foreign Body Reaction and Prevents Fibrosis

Peri-implant fibrosis (PIF) increases the postsurgical risks after implantation and limits the efficacy of the implantable drug delivery systems (IDDS). Pirfenidone (PF) is an oral anti-fibrotic drug with a short (<3 h) circulation half-life and strong adverse side effects. In the current study,...

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Detalles Bibliográficos
Autores principales: Fayzullin, Alexey, Churbanov, Semyon, Ignatieva, Natalia, Zakharkina, Olga, Tokarev, Mark, Mudryak, Daniil, Khristidis, Yana, Balyasin, Maxim, Kurkov, Alexandr, Golubeva, Elena N., Aksenova, Nadejda A., Dyuzheva, Tatyana, Timashev, Peter, Guller, Anna, Shekhter, Anatoly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389617/
https://www.ncbi.nlm.nih.gov/pubmed/34440057
http://dx.doi.org/10.3390/biomedicines9080853

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389617/
https://www.ncbi.nlm.nih.gov/pubmed/34440057
http://dx.doi.org/10.3390/biomedicines9080853

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