Development and Characterization of a Novel Peptide—Drug Conjugate with DM1 for Treatment of FGFR2-Positive Tumors

A maytansin derivative, DM1, is a promising therapeutic compound for treating tumors, but is also a highly poisonous substance with various side effects. For clinical expansion, we tried to develop novel peptide–drug conjugates (PDCs) with DM1. In the study, a one-bead one-compound (OBOC) platform w...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Yayu, Li, Yadan, Cao, Jieqiong, Meng, Qilin, Li, Xiaocen, Zhang, Yibo, Lam, Kit S., Hong, An, Liu, Ruiwu, Chen, Xiaojia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389697/
https://www.ncbi.nlm.nih.gov/pubmed/34440055
http://dx.doi.org/10.3390/biomedicines9080849

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389697/
https://www.ncbi.nlm.nih.gov/pubmed/34440055
http://dx.doi.org/10.3390/biomedicines9080849

Ejemplares similares