Synthesis and Preclinical Validation of Novel Indole Derivatives as a GPR17 Agonist for Glioblastoma Treatment

[Image: see text] The discovery of a potential ligand-targeting G protein-coupled receptor 17 (GPR17) is important for developing chemotherapeutic agents against glioblastoma multiforme (GBM). We used the integration of ligand- and structure-based cheminformatics and experimental approaches for iden...

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Detalles Bibliográficos
Autores principales: Nguyen, Phung, Doan, Phuong, Rimpilainen, Tatu, Konda Mani, Saravanan, Murugesan, Akshaya, Yli-Harja, Olli, Candeias, Nuno R., Kandhavelu, Meenakshisundaram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389915/
https://www.ncbi.nlm.nih.gov/pubmed/34304559
http://dx.doi.org/10.1021/acs.jmedchem.1c00277

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389915/
https://www.ncbi.nlm.nih.gov/pubmed/34304559
http://dx.doi.org/10.1021/acs.jmedchem.1c00277

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